Dexmedetomidine Ever Pharma Injection
Dexmedetomidine
5 amp/box
ZAS Corporation
| Pack size | 5 amp/box |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 1470.00 AED |
Indications
Dexmedetomidine Ever Pharma Injection is used for:
ICU Sedation, Fiberoptic Intubation, Procedural Sedation
Adult Dose
ICU Sedation
Load: 1 mcg/kg IV over 10 minutes
Maintenance 0.2-1.4 mcg/kg/hr IV
Titrate less frequently than q30min to prevent hypotension
Fiberoptic Intubation
Load: 1 mcg/kg IV over 10 minutes
Maintenance 0.7 mcg/kg/hr IV
Procedural Sedation
Load: 1 mcg/kg IV over 10 minutes
Maintenance 0.6 mcg/kg/hr IV titrate to effect (usually 0.2-1 mcg/kg/hr)
Titrate less frequently than q30min to prevent hypotension
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment (SL, BUC)
All severities: No dosage adjustment necessary
Administration
IV Preparation
Dilute in NS
IV Administration
Infuse loading dose over 10 min
Contra Indications
2nd or 3rd degree AV block (unless paced), uncontrolled hypotension, acute cerebrovascular disorders.
Precautions
Bradycardia and Sinus Arrest: Consider decreasing or stopping dexmedetomidine HCl infusion; decreasing or stopping other medications that depress sinus node function; administering anticholinergic agents (e.g., glycopyrrolate, atropine); and/or administering pressor agents.
Hypotension: Consider decreasing or stopping dexmedetomidine HCl infusion; increasing rate of intravenous fluid administration; elevating lower extremities, and/or administering pressor agents.
Transient Hypertension: Observed primarily during administration of loading dose. Consider reducing loading infusion rate.
Arousability: Patients can become aroused/alert with stimulation; this alone should not be considered as lack of efficacy.
Prolonged exposure to dexmedetomidine beyond 24 hours may be associated with tolerance and tachyphylaxis and a dose-related increase in adverse events.
Pregnancy-Lactation
Pregnancy
There are no adequate and well-controlled studies of use in pregnant women
In an in vitro human placenta study, placental transfer of dexmedetomidine occurred
Animal studies
In pregnant rats, dexmedetomidine placental transfer observed when radiolabeled dexmedetomidine was administered SC
Thus, fetal exposure should be expected in humans; use during pregnancy only if potential benefits justify potential fetal risk
Lactation
Unknown if excreted in human milk
Radio-labeled dexmedetomidine administered SC to lactating female rats was excreted in milk
Because many drugs are excreted in human milk, caution should be exercised when administered to breastfeeding women
Interactions
Enhanced pharmacologic effects of anaesth, sedatives, hypnotics, opiate agonists, other vasodilators or drugs that have negative chronotropic effects (e.g. cardiac glycosides).
Anesthetics, sedatives/hypnotics, opioids: Can potentiate sedating effects.
Consider reducing dosage of dexmedetomidine HCl or co-administered drug.
Contraindicated (1)
eliglustat
Serious (14)
calcium/magnesium/potassium/sodium oxybates
givinostat
hydrocodone
landiolol
lonafarnib
metoclopramide intranasal
olopatadine intranasal
ponesimod
ropeginterferon alfa 2b
sodium oxybate
sufentanil SL
valerian
vortioxetine
zuranolone
Adverse Effects
Side effects of Dexmedetomidine :
>10%
Hypotension (25-28%)
Hypertension (12-16%)
Nausea (9-11%)
1-10%
Bradycardia (5-7%)
Pyrexia (4-5%)
Atrial fibrillation (4%)
Dry mouth (3-4%)
Vomiting (3-4%)
Hypoxia (2-4%)
Hypovolemia (3%)
Atelectasis (3%)
Tachycardia (2-3%)
Postprocedural hemorrhage (2-3%)
Anemia (2-3%)
Agitation (2%)
Hyperthermia (2%)
Pain (2%)
Hyperglycemia (2%)
Chills or rigors (2%)
Hyperglycemia (2%)
Oliguria (2%)
Thirst (2%)
Acidosis (1-2%)
Pleural effusion (1-2%)
Pulmonary edema (1%)
Hypocalcemia (1%)
Urine output decreased (1%)
Sinus tachycardia (1%)
<1%
Ventricular tachycardia
Wheezing
Peripheral edema
Mechanism of Action
Centrally acting alpha2-adrenoceptor agonist that has sedative and anesthetic properties possibly by activating G-proteins in the brainstem, which results in the inhibition of norepinephrine release.
Note
Dexmedetomidine Ever Pharma 5 amp/box Injection manufactured by ZAS Corporation. Its generic name is Dexmedetomidine. Dexmedetomidine Ever Pharma is availble in Bangladesh.
Farmaco BD drug index information on Dexmedetomidine Ever Pharma Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.