Delkof Plus Syrup

Dextromethorphan HBr + Phenylephrine HCl + Triprolidine HCl

(10mg+30mg+1.25mg)/5ml

Popular Pharmaceuticals Ltd.

Pack size	100ml
Dispensing mode
Source
Agent
Retail Price	100.00 AED

Indications

Delkof Plus Syrup is used for: Non-productive cough, common cold, hay fever (allergic rhinitis), cough due to minor throat or bronchial irritation, runny nose, sneezing, itching of the nose or throat, itchy, watery eyes, nasal congestion, reduces swelling of nasal passages

Adult Dose

Adults: Oral 1 teaspoonful (5 ml) 4 times a day.

Child Dose

Oral Children over 12 years: 1 teaspoonful (5 ml) 4 times a day. 6-12 years: 1/2 teaspoonful (2.5 ml) 4 times a day.

Renal Dose

Administration

Take with or without food.

Contra Indications

This combination is contraindicated in patients with a known hypersensitivity to Dextromethorphan, Phenylephrine, or Triprolidine, as well as in persons under treatment with Monoamine Oxidase Inhibitor within 2 weeks of stopping such treatment. It should be avoided in patients with liver disease or asthmatic patients

Precautions

This preparation may cause drowsiness. If affected, do not drive motor vehicle or operate machinery. Avoid alcoholic drink while on this medication. Use with caution in patients with epilepsy, prostatic hypertrophy, glaucoma, hepatic disease, hypertension, heart disease, diabetes, hyperthyroidism, patients with stenosing peptic ulcer, pyloro-duodenal obstruction or bladder neck obstruction, unless under the medical advice and supervision. If symptoms do not improve within one week or accompanied with high fever, consult a physician before continuing use.

Pregnancy-Lactation

There are no specific data on use of this combination during pregnancy & lactation

Interactions

Taking certain MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking isocarboxazid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, or tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Caution should be excercised while taking this drug with antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray), antispasmodics (e.g. atropine, belladonna alkaloids), beta blockers (e.g. metoprolol, atenolol), drugs for Parkinson’s disease (e.g. anticholinergics such as benztropine, trihexyphenidyl), guanethidine, certain inhaled anesthetics (e.g. halothane), methyldopa, reserpine, scopolamine, tricyclic antidepressants (e.g. amitriptyline, desipramine), anti seizure drugs (e.g. carbamazepine), medicine for sleep or anxiety (e.g. alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g. codeine), psychiatric medicines (e.g. chlorpromazine, risperidone, amitriptyline, trazodone).

Adverse Effects

Side effects of Dextromethorphan HBr + Phenylephrine HCl + Triprolidine HCl : Side effects of Dextromethorphan appears to be rare and may include drowsiness. Prostatic enlargement could have been an important predisposing factor. Excitability may occur, especially in children Other less common side effects may include transient hypertension, dry mouth, restlessness, palpitations, allergic reactions such as rashes, tightness of chest, thickening of bronchial secretions, toxic psychosis and blood dyscrasia.

Mechanism of Action

This preparation is a mixture of antitussive, decongestant and antihistamine agent. Dextromethorphan is a safe, effective, non-narcotic antitussive agent which has a central action on the cough centre in the medulla. Although structurally related to Morphine, it has no analgesic and habit forming properties and in general it has little sedative activity. Phenylephrine is a decongestant that shrinks blood vessels in the nasal passage. It is used to treat nasal and sinus congestion of the tubes that drain fluid from inner ear. Triprolidine provides symptomatic relief in conditions believed to depend wholly or partly upon the triggered release of histamine. It is a potent competitive histamine H1-receptor antagonist of the pyrrolidine class with mild central nervous system depressant properties which may cause drowsiness.

Note

Delkof Plus (10mg+30mg+1.25mg)/5ml Syrup manufactured by Popular Pharmaceuticals Ltd.. Its generic name is Dextromethorphan HBr + Phenylephrine HCl + Triprolidine HCl. Delkof Plus is availble in Bangladesh. Farmaco BD drug index information on Delkof Plus Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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