D-Best Soft Gelatin Capsule
Cholecalciferol (Vit. D3)
20000 IU
Pacific Pharmaceuticals Ltd.
| Pack size | 10's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 20.00 AED |
Available as:
Indications
D-Best Soft Gelatin Capsule is used for:
Osteoporosis, Hypoparathyroidism, Rickets, Osteomalacia,Vitamin D Deficiency, Pseudohypoparathyroidism, Familial hypophosphatemia
Adult Dose
Oral:
Nutritional deficiency
Cholecalciferol (Vitamin D3) is recommended 5-10 mcg/day
Capsule:
Treatment of Vitamin D deficiency: 40000 IU/week for 7 weeks, followed by maintenance therapy 1000-2000 IU/day.
Prevention of vitamin D deficiency: 20000 IU/Month.
Chewable tablet:
Cholecalciferol (Vitamin D3) is recommended 100 IU (1 tablet) daily.
Oral solution:
Cholecalciferol (Vitamin D3) is recommended 5-10 mcg or 1-2ml (200-400 IU)/day.
IM:
Nutritional deficiency
Cholecalciferol (Vitamin D3) is recommended 1-2ml (200-400 IU)/day
Osteoporosis
Prophylaxis and treatment
>50 years: 800-1000 IU (20-25 mcg) PO once daily with calcium supplements. May also be given via IM inj.
Hypoparathyroidism
50,000-200,000 IU (0.625-5 mg) PO once daily with calcium supplements. May also be given via IM inj.
Child Dose
For Prevention:
Children
Oral Drop: (200IU = 1 drop)
Oral Solution: (200IU = 1 ml)
For Prevention with an identified risk, the recommended dose is 1-2 drops (200-400 IU) per day
Preterm infant: 200 - 400 IU/day
Children 0-1 yr: 200-400 IU/day
Children >1 Yr: 600-1000 lU/day
Children 0-11 years old: with an identified risk, the recommended dose is 2 drops (400 IU) per day
Adolescents 12-18 years old: with an identified risk, the recommended dose is 3-4 drops (600-800 IU) per day.
Treatment of deficiency:
Preterm infant: 200 IU/day
Infant <3 months (term): 400 IU/day
Children> 3-12 months: 1000 IU/day
Children> 1-11 yrs: 2000 IU/day for 6 weeks.
Children>11years: 4000 IU per day
The daily dose should not exceed 1000 IU (5 drops) per day for infants <1 year.
The daily dose should not exceed 2000 IU per day for children 1-10 years.
Capsule/Tablet
Children: (12-18 Years)
Treatment of Vitamin D deficiency, 12-18 years: 20000 IU, once every 2 weeks for 6 weeks OR 4000 IU per day
Prevention of Vitamin D deficiency, 12-18 years: 20000 IU, once every 6 weeks.
For Prevention with an identified risk, the recommended dose is 3-4 drops (600-800 IU) per day.
(200IU = 1drop)
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Colecalciferol is contraindicated in all diseases associated with hypercalcemia.
It is also contraindicated in patients with known hypersensitivity to Colecalciferol (or medicines of the same class) and any of the constituent excipients. Colecalciferol is contraindicated if there is evidence of vitamin D toxicity.
Precautions
People with the following conditions should exercise caution when considering taking vitamin D supplements:
High blood Calcium or Phosphorus level
Heart problems
Kidney disease
Vitamin D must be taken with adequate amounts of both Calcium and Magnesium supplementation. When Calcium level is low (due to insufficient vitamin D and calcium intake), the body activates the parathyroid gland, which produces PTH (parathyroid hormone). This hormone kick starts vitamin D hormone production and assists removal of Calcium from the bones to be used in more important functions such as neutralizing body acidity.
Pregnancy-Lactation
Studies have shown safe use of doses up to 4000 IU during pregnancy. The recommended daily intake for pregnant women is 400 IU, however, in women who are considered to be Vitamin D3 deficient a higher dose may be required. During pregnancy women should follow the advice of their medical practitioner as their requirements may vary depending on the severity of their disease and their response to treatment
Vitamin D3 and its metabolites are excreted in breast milk. Overdose in infants induced by nursing mothers has not been observed; however, when prescribing additional vitamin D3 to a breast-fed child the practitioner should consider the dose of any additional vitamin D3 given to the mother.
Interactions
Increased risk of hypercalcaemia if given with thiazide diuretics, calcium or phosphate.
Antiepileptics (e.g. carbamazepine, phenobarbitone, phenytoin & primidone) may increase vitamin D requirements.
Rifampicin & isoniazid may reduce efficacy of vitamin D.
Corticosteroids may counteract the effect of vitamin D. Digoxin or any cardiac glycoside.
Reduced absorption when taken with cholestyramine, colestipol, mineral oil, orlistat. Ketoconazole.
Adverse Effects
Side effects of Cholecalciferol (Vit. D3) :
Generally all nutritional supplements are considered to be safe and well tolerable. However, few side-effects can generally occur including hypercalcaemia syndrome or Calcium intoxication (depending on the severity and duration of hypercalcaemia), occasional acute symptoms include anorexia, headache, dry mouth, nausea, vomiting, abdominal pain or stomach ache and constipation with the administration of Colecaciferol.
Mechanism of Action
Vitamin D3 is a fat-soluble sterol. It is necessary for the regulation and regulation of calcium and phosphate homoeostasis and bone mineralisation. Vitamin D is also essential for healthy bones as it aids in Calcium absorption from the GI tract. In addition to this it stimulates bone formation.
Note
D-Best 20000 IU Soft Gelatin Capsule manufactured by Pacific Pharmaceuticals Ltd.. Its generic name is Cholecalciferol (Vit. D3). D-Best is availble in Bangladesh.
Farmaco BD drug index information on D-Best Soft Gelatin Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.