Cyclovin Tablet
Dicycloverine (Dicyclomine) Hydrochloride
10mg
Somatec Pharmaceuticals Ltd.
| Pack size | 100's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 2.01 AED |
Available as:
Indications
Cyclovin Tablet is used for:
Gastrointestinal tract spasm, Intestinal hypermotility, Irritable bowel syndrome (IBS)
Adult Dose
Oral
Tablet/Syrup
Gastrointestinal tract spasm
Adult: 10-20 mg tid.
Irritable Bowel Syndrome
20 mg PO q6hr; may increase up to 40 mg q6hr;
If efficacy not achieved in 2 weeks or adverse effects require dose <80 mg/day, therapy should be discontinued.
Safety data not available for doses > 80 mg/day for periods > 2 weeks
Intramuscular
Gastrointestinal tract spasm
Adult: 20 mg 4 times a day given only for 1-2 days.
Replace with oral therapy as soon as possible.
Irritable Bowel Syndrome
10-20 mg IM q6hr; not to exceed 80 mg/day IM
IM use should not be longer than 1-2 days; replace IM with PO as soon as possible
Child Dose
Oral
Tablet/Syrup
Gastrointestinal tract spasm
6 months - 2 yr: 5-10 mg 3-4 times daily.
Child: 2-12 yr: 10 mg tid;
Child 12–17 yr: 10–20 mg 3 times a day
Renal Dose
Administration
Take 30-60 minutes before a meal
Contra Indications
Hypersensitivity to dicyclomine or any anticholinergic drugs
Closed-angle glaucoma
Myasthenia gravis
Hemorrhage with cardiovascular instability
Paralytic ileus
Breast-feeding
Intestinal atony of elderly/debilitated patients
Toxic megacolon
GI obstruction
Obstructive uropathy
Severe ulcerative colitis
Reflux esophagitis
Infants aged <6 months (reports of seizure, respiratory failure, death)
Precautions
Caution in renal/hepatic impairment
Caution in benign prostatic hyperplasia
Caution in congestive heart failure
Caution in tachycardia secondary to cardiac insufficiency or thyrotoxicosis, hypertension, coronary artery disease, chronic obstructive pulmonary disease, hiatal hernia, mitral stenosis, brain damage or spastic paralysis in children, salivary secretion disorder, Down syndrome, autonomic neuropathy, hyperthyroidism
Tachyarrhythmia; assess before administration
Toxin-mediated diarrhea
Elderly (Beers Criteria)
May cause drowsiness; avoid alcohol
For IM injection only; IV injection may result in thrombosis or thrombophlebitis and injection-site reactions
Heat prostration can occur (fever and heat stroke due to decreased sweating)
Psychosis in patients sensitive to anticholinergic drugs reported (eg, elderly, mentally ill individuals); signs and symptoms resolve within 12-24 hr after discontinuation
Incomplete intestinal obstruction: Diarrhea may be an early symptom, especially in patients with ileostomy or colostomy
Salmonella dysenteric patients: Due to risk of toxic megacolon
Use caution in patients with mild-moderate ulcerative colitis
Effects may be potentiated when used with other sedative drugs or ethanol
Serious respiratory reactions, CNS symptoms, and deaths reported following administration to infants
Pregnancy-Lactation
Interactions
Antagonise the effect of drugs that affect GI motility e.g. metoclopramide.
Absorption affected by concurrent admin with antacids.
Contraindicated (0)
Serious (8)
glucagon
glucagon intranasal
glycopyrronium tosylate topical
pramlintide
revefenacin
secretin
sofpironium topical
umeclidinium bromide/vilanterol inhaled
Adverse Effects
Side effects of Dicycloverine (Dicyclomine) Hydrochloride :
>10%
Dizziness (40%)
Xerostomia (33%)
Blurred vision (27%)
1-10%
Somnolence (9%)
Nervousness (6%)
Weakness (7%)
Frequency Not Defined
Abdominal distension
Confusional state
Cycloplegia
Delirium
Dermatitis
Erythema
Fatigue
Hallucinations
Insomnia
Malaise
Palpitation
Rash
Syncope
Potentially Fatal: Respiratory arrest in infants <10 wk.
Mechanism of Action
Dicycloverine HCl relieves smooth muscle spasm in the GI and urinary tract. This effect is partly due to antimuscarinic action and partly direct action on the smooth muscle.
Note
Cyclovin 10mg Tablet manufactured by Somatec Pharmaceuticals Ltd.. Its generic name is Dicycloverine (Dicyclomine) Hydrochloride. Cyclovin is availble in Bangladesh.
Farmaco BD drug index information on Cyclovin Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.