Coprin Syrup
Dextromethorphan + Pseudoephedrine HCL +Triprolidine HCL
10 mg+30 mg+1.25 mg
Doctor's Chemicals Works Ltd.
| Pack size | 100ml bot |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 5.00 AED |
Indications
Coprin Syrup is used for:
Flu, Colds, Runny nose, Dry coughs, Non-productive cough, Nasal congestion, Sneezing, Itchy & watery eyes
Adult Dose
Oral
Cough and common cold
Adult: 2 teaspoonful three times a day.
Child Dose
Children
Over 12 years 2 teaspoonfuls three times a day
6-12 years 1 teaspoonful three times a day
2-6 years 1/2 teaspoonful three times a day
Renal Dose
Administration
Contra Indications
Patients at risk of developing resp failure.
During an acute attack.
Patients receiving MAOI or for 2 wk after discontinuing them.
Persistent or chronic cough.
Precautions
3rd trimester of pregnancy; atopic childn; child <1 yr; sedated or debilitated patients; patients confined to supine position; history of asthma.
Moderate to severe renal impairment; liver disease.
Use with caution in patients with epilepsy, prostatic hypertrophy, glaucoma, hepatic disease, hypertension, heart disease, diabetes, hyperthyroidism. If symptoms do not improve within one week or accompanied with high fever, consult a physician before continuing use.
Pregnancy-Lactation
Interactions
Dextromethorphan: Tricyclic antidepressants (TCAs), antipsychotics, anxiolytics and hypnotics, cimetidine, ciprofloxacin, domperidone, metoclopramide, mexiletine, CYP2D6 inhibitors, ritonavir, alcohol.
Potentially Fatal: Memantine, moclobemide.
Triprolidine + Pseudoephedrine: Increased BP with other sympathomimetic agents (e.g. decongestants, TCA, appetite suppressants). Reduced hypotensive effects of methyldopa, ?- and ?-adrenergic blockers. Increased side effects (e.g. somnolence, agitation) with atomoxetine.
Potentially Fatal: Increased risk of hypertensive crisis with furazolidine, avoid concurrent use. Increased risk of hypertensive crisis with MAOIs; avoid concurrent use or within 2 wk after stopping MAOIs. Increased risk of psychosis with bromocriptine.
Adverse Effects
Side effects of Dextromethorphan + Pseudoephedrine HCL +Triprolidine HCL :
Dizziness, GI disturbances.
Mechanism of Action
Triprolidine is a potent competitive histamine H1-receptor antagonist with mild sedating and antimuscarinic properties. Pseudoephedrine, an alpha- and beta-adrenergic receptor agonist, mediates vasoconstriction via direct stimulation of alpha-adrenergic receptors of the respiratory mucosa. Dextromethorphan is a centrally acting cough suppressant which acts on the cough centre in the medulla.
Note
Coprin 10 mg+30 mg+1.25 mg Syrup manufactured by Doctor's Chemicals Works Ltd.. Its generic name is Dextromethorphan + Pseudoephedrine HCL +Triprolidine HCL. Coprin is availble in Bangladesh.
Farmaco BD drug index information on Coprin Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.
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