Cinaryl Plus Tablet
Cinnarizine + Dimenhydrinate
20 mg + 40 mg
Opsonin Pharma Limited
| Pack size | 100's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 2.00 AED |
Indications
Cinaryl Plus Tablet is used for:
Vertigo
Adult Dose
Oral
Adult: 1 tablet 3 times daily.
Child Dose
Children and adolescents under the age of 18 years: Not recommended
Renal Dose
Administration
Should be taken with food.
Contra Indications
Cinnarizine and Dimenhydrinate is contraindicated in patients with known hypersensitivity to the active substances or to any of the excipients.
Cinnarizine and Dimenhydrinate should not be used in patients with angle-closure glaucoma, convulsions, suspicion of raised intracranial pressure, and alcohol abuse or urine retention due to urethroprostatic disorders.
Cinnarizine and Dimenhydrinate should not be used by patients with severe hepatic impairment.
Precautions
Hypotension; pregnancy; lactation; elderly. May impair ability to drive or operate machineries.
Caution should be exercised when administering Cinnarizine and Dimenhydrinate to patients with Parkinson’s disease.
Cinnarizine and Dimenhydrinate do not reduce blood pressure significantly; however, it should be used with caution in hypotensive patients. Cinnarizine and Dimenhydrinate should be taken after meals to minimize any gastric irritation.
Pregnancy-Lactation
Pregnancy: The safety of Revert in human pregnancy has not been established.
Lactation: Dimenhydrinate and cinnarizine are excreted in human breast milk. Revert should not be taken by women who are breastfeeding.
Interactions
Cinnarizine: CNS depressant effect enhanced with alcohol. Action potentiated by domperidone.
Dimenhydrinate: Physically incompatible with aminophylline, hydrocortisone, phenothiazines and some barbiturates in solution.
Potentially Fatal: Potentiates the sedative effects of CNS depressants, including alcohol, barbiturates, opioid analgesics, sedatives and neuroleptics. MAOIs, atropine, TCAs enhance the antimuscarinic effect. Masks ototoxicity produced by aminoglycoside antibiotics.
Adverse Effects
Side effects of Cinnarizine + Dimenhydrinate :
Extrapyramidal symptoms sometimes associated with severe depression. Drowsiness, headache, GI upsets, unsteadiness, headache; rarely skin and hypersensitivity reactions, dry mouth, blurred vision, urinary difficulty or retention, constipation and increased gastric reflux, fatigue. Hypolipidaemic effect.
Mechanism of Action
Cinnarizine has calcium-channel blocking activity selective for arterial smooth muscle. It also has some antihistamine activity. Cinnarizine acts as a labyrinthine sedative. It also improves microcirculation by reducing ischaemia-induced blood viscosity.
Dimenhydrinate is an antihistamine which also has antimuscarinic and central sedative action. It also exerts a depressant action on hyperstimulated labyrinthine function.
Note
Cinaryl Plus 20 mg + 40 mg Tablet manufactured by Opsonin Pharma Limited. Its generic name is Cinnarizine + Dimenhydrinate. Cinaryl Plus is availble in Bangladesh.
Farmaco BD drug index information on Cinaryl Plus Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.