Cetrolix Subcutaneous Injection
Cetrorelix
0.25mg
Eskayef Pharmaceuticals Ltd.
| Pack size | 1's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 2500.00 AED |
Indications
Cetrolix Subcutaneous Injection is used for:
Assisted reproductive technologies, In-vitro fertilization, Infertility Treatment
Adult Dose
Subcutaneous Injection
Assisted reproductive technologies
Adult: As acetate: equivalent to 0.25 mg cetrorelix either in the morning beginning on the day 5 or 6 of ovarian stimulation or in the evening beginning on day 5, and continued until ovulation induction.
Infertility Treatment
Indicated for inhibition of premature LH surges in women undergoing controlled ovarian stimulation
Cycle Day 2 or 3: Ovarian stimulation with gonadotropins (FSH, hMG) initiated; adjust dose according to individual response
Early- to mid-follicular phase: Initiate cetrorelix 0.25 mg SC qDay
Cetrotide 0.25 mg administered on either stimulation day 5 (morning or evening) or day 6 (morning) and continued qDay until day of hCG administration
When ultrasound assessment shows sufficient number of adequate size follicles, administer hCG to induce ovulation and final maturation of the oocytes
Do not administer hCG if ovaries show excessive treatment response to gonadotropins (to reduce chance of developing ovarian hyperstimulation syndrome [OHSS])
Child Dose
Renal Dose
Renal impairment
Mild-to-moderate: Dose adjustment not described by manufacturer
Severe: Contraindicated
Administration
Administration
Cetrorelix 0.25 mg and 3 mg can be administered by the patient herself after appropriate
instructions by her doctor.
Directions for using Cetrorelix 0.25 mg and 3 mg with the enclosed needles and pre-filled syringe:
1. Wash hands thoroughly with soap and water.
2. Flip off the plastic cover of the vial and wipe the aluminum ring and the rubber stopper with an alcohol swab.
3. Twist the injection needle with the yellow mark (20 gauge) on the pre-filled syringe.
4. Push the needle through the center of the rubber stopper of the vial and slowly inject the solvent into the vial.
5. Leaving the syringe in the vial, gently swirl the vial until the solution is clear and without residues. Avoid forming bubbles.
6. Draw the total contents of the vial into the syringe. If necessary, invert the vial and pull back the needle as far as needed to withdraw the entire contents of the vial.
7. Replace the needle with the yellow mark by the injection needle with the grey mark (27 gauge).
8. Invert the syringe and push the plunger until all air bubbles have been expelled.
9. Choose an injection site in the lower abdominal area, preferably around, but staying at least one inch away from the navel. If you are on a multiple dose (0.25 mg) regimen, choose a different injection site each day to minimize local irritation. Use the second alcohol swab to clean the skin at the injection site and allow alcohol to dry. Gently pinch up the skin surrounding the site of injection.
10. Inject the prescribed dose as directed by your doctor, nurse or pharmacist.
11. Use the syringe and needles only once. Dispose of the syringe and needles properly after use. If available, use a medical waste container for disposal.
Contra Indications
Hypersensitivity to cetrorelix acetate, extrinsic peptide hormones or mannitol.
Known hypersensitivity to GnRH or any other GnRH analogs.
Known or suspected pregnancy, and lactation.
Severe renal impairment.
Precautions
May cause elevations of hepatic enzymes: ALT, AST, GGT, AP
Exclude pregnancy before initiating therapy
Monitor closely for hypersensitivity following first injection
Pregnancy-Lactation
Pregnancy Category: X
Lactation: Excretion in milk unknown/contraindicated
Interactions
In vitro investigations have shown that interactions are unlikely with medications that are metabolised by cytochrome P-450 or glucuronised or conjugated in some other way. However, the possibility of interactions with commonly used medicinal products can not entirely be excluded.
Adverse Effects
Side effects of Cetrorelix :
1-10%
Ovarian hyperstimulation syndrome (4%),Nausea (1%),Hepatic enzyme elevation (1-2%),Headache (1%)
<1%
Erythema at injection site,Itching,Pruritus,Swelling,Redness,Hypotension,Rash,Cough
Mechanism of Action
Cetrorelix, a synthetic decapeptide analog of naturally occurring gonadorelin, is a gonadorelin antagonist. It competitively blocks gonadorelin receptors on the anterior piyuitary gonadotroph and the subsequent transduction pathway, inducing a rapid, reversible suppression of gonadotrophin secretion.
Note
Cetrolix 0.25mg Subcutaneous Injection manufactured by Eskayef Pharmaceuticals Ltd.. Its generic name is Cetrorelix. Cetrolix is availble in Bangladesh.
Farmaco BD drug index information on Cetrolix Subcutaneous Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.