Ceftiben Capsule
Ceftibuten
400mg
Square Pharmaceuticals PLC.
| Pack size | 6's Pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 120.00 AED |
Available as:
Indications
Ceftiben Capsule is used for:
Respiratory tract infections, Urinary tract infections, Acute Bacterial Exacerbations of Chronic Bronchitis, Acute Bacterial Otitis Media, Pharyngitis and Tonsillitis
Adult Dose
Oral
Respiratory tract infections, Urinary tract infections
Adult: 400 mg once daily for 10 days.
Child Dose
Child:
<6 months: Safety and efficacy not established
6-12 years old or <45 kg: 9 mg/kg PO once daily; 400 mg/day PO for 10 days maximum
>12 years old or >45 kg: 400 mg once daily for 10 days.
Renal Dose
Renal Impairment
CrCl 30-49 mL/min: 200 mg PO qDay or 4.5 mg/kg qDay
CrCl 5-29 mL/min: 100 mg PO qDay or 2.25 mg/kg qDay
Supplement following hemodialysis
Administration
Susp: Should be taken on an empty stomach. Take 2 hr before or 1 hr after meals.
Cap: May be taken with or without food.
Contra Indications
Hypersensitivity to cephalosporins.
Precautions
Hypersensitivity to penicillins; renal impairment; Porphyria.
Diabetics: oral suspension contains 1 g sucrose/tsp
Modify dosage in severe renal impairment;
prolonged use may result in superinfection;
caution in seizure disorder;
may cause antibiotic-associated colitis
Monitor renal and haematologic status.
Pregnancy-Lactation
Pregnancy Category: B
Lactation: excretion in milk unknown; use with caution
Interactions
Enhanced nephrotoxicity of aminoglycosides.
Increased serum concentration w/ probenecid.
Decreased serum concentration w/ zinc salts.
Contraindicated (0)
Serious (4)
BCG vaccine live
cholera vaccine
microbiota oral
typhoid vaccine live
Adverse Effects
Side effects of Ceftibuten :
1-10%
Increased BUN (4%),Nausea (4%),Diarrhea (3%),Headache (3%),Increased eosinophils (3%),Decreased hemoglobin (2%),Dyspepsia (2%),Thrombocytosis (2%),Abdominal pain (1%),Dizziness (1%),Increased ALT (1%),Increased bilirubin (1%),Vomiting (1%)
<1%
Anorexia,Candidiasis,Constipation,Dysuria,Agitation,Fatigue,Insomnia,Irritability,Paresthesia,Rigors,Diaper rash,Urticaria,Dry mouth,Dyspnea,Nasal congestion,Increased transaminases,Increased creatinine,Leukopenia
Potentially Fatal: Pseudomembranous colitis.
Mechanism of Action
Ceftibuten inhibits bacterial cell wall synthesis. It is stable to hydrolysis by many beta-lactamases and has greater activity than 1st or 2nd generation cephalosporins against gm-ve bacteria. It is less active in vitro than cefexime against S. pneumoniae.
Note
Ceftiben 400mg Capsule manufactured by Square Pharmaceuticals PLC.. Its generic name is Ceftibuten. Ceftiben is availble in Bangladesh.
Farmaco BD drug index information on Ceftiben Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.