Bethacol Tablet
Bethanechol
25 mg
UniMed UniHealth Pharmaceuticals Ltd.
| Pack size | 30's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 20.00 AED |
Indications
Bethacol Tablet is used for:
Urinary Retention
Adult Dose
Oral
Acute postoperative nonobstructive urinary retention, Acute postpartum nonobstructive urinary retention, Neurogenic atony of the bladder with retention
Adult: Initially, 5-10 mg
Repeat the initial dose at hourly intervals until an effective response is achieved or until the Maximum of 50 mg is given.
Usual dose: 10-50 mg 3-4 times daily.
Dose must be individualized based on response, type and severity of the condition.
Child Dose
Renal Dose
Administration
Should be taken on an empty stomach.
Contra Indications
Hypersensitivity, hyperthyroidism, peptic ulcer, latent or active bronchial asthma; coronary artery disease, recent MI, pronounced bradycardia or hypotension, vasomotor instability; epilepsy, parkinsonism; conditions when increased muscular activity of the gastrointestinal tract or urinary bladder may prove harmful (e.g. following recent urinary bladder surgery, gastrointestinal resection and anastomosis, possible gastrointestinal obstruction); conditions wherein the strength or integrity of the gastrointestinal or bladder wall is questionable; mechanical obstruction of the gastrointestinal and genitourinary tract; bladder neck obstruction, acute inflammatory lesions of the gastrointestinal tract, spastic gastrointestinal disturbances, peritonitis, marked vagotonia.
Precautions
Since bethanechol contracts the bladder there is potential for influx infection if the sphincter fails to relax.
Patient with bacteriuria. Pregnancy and lactation
Pregnancy-Lactation
Pregnancy Category: C
Lactation: It is not known whether this drug is excreted in milk. Because of the potential for serious adverse reactions from bethanechol chloride in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Interactions
Additive effects and increased toxicity with other cholinergic drugs or anticholinesterase agents (e.g. neostigmine). May cause a critical fall in blood pressure (usually preceded by severe abdominal symptoms) when given with ganglionic blocking agents. Atropine, procainamide, quinidine, epinephrine, and other sympathomimetic amines may antagonise the effects of bethanechol.
Adverse Effects
Side effects of Bethanechol :
Frequency Not Defined
Abdominal cramps
Belching
Borborygmi colicky pain
Bronchial constriction
Diarrhea
Flushing
Increased gastric motility
Headache
Hypotension
Lacrimation
Miosis
Nausea
Vomiting
Salivation
Urinary urgency
Mechanism of Action
Bethanechol, a choline ester, is a quaternary ammonium parasympathomimetic agent that exhibits the muscarinic activity of acetylcholine. It acts by directly stimulating the parasympathetic nervous system, thereby releasing acetylcholine at the nerve endings. It increases bladder muscle tone resulting in contractions which initiate urination. Additionally, it stimulates gastric motility, enhances gastric tone, and restores impaired rhythmic peristalsis.
Note
Bethacol 25 mg Tablet manufactured by UniMed UniHealth Pharmaceuticals Ltd.. Its generic name is Bethanechol. Bethacol is availble in Bangladesh.
Farmaco BD drug index information on Bethacol Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.