Bet Cl Cream
Betamethasone 0.05% + Clotrimazole 1% Topical
0.05% + 1%
Acme Laboratories Ltd.
| Pack size | 10gm tube |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 29.20 AED |
Available as:
Indications
Bet Cl Cream is used for:
Inflammed tinea pedis, tinea cruris, tinea corporis.
Adult Dose
Adult:
Topical:
Tinea pedis: Apply a thin film to the affected skin areas twice a day for 2 weeks. Do not use longer than 4 weeks.
Tinea cruris and Tinea corporis: Apply a thin film to the affected skin area twice a day for 1 week. Do not use longer than 2 weeks.
Child Dose
<17 years: Safety and efficacy not established
Renal Dose
Administration
Do not use with occlusive dressings.
Contra Indications
Hypersensitivity.
Precautions
Betamethasone + Clotrimazole cream can cause reversible HPA axis suppression with the potential for glucocorticosteroid insufficiency during and after withdrawal of the treatment. Risk factor(s) are use of high potency topical corticosteroid, use over a large surface area or to areas under occlusion, prolonged use, altered skin barrier, liver failure, and young age. Modify use should HPA axis suppression develop.
Pediatric patients may be more susceptible to systemic toxicity.
The use of Betamethasone + Clotrimazole cream in the treatment of diaper dermatitis is not recommended.
Topical corticosteroid products may increase the risk of cataracts and glaucoma. If visual symptoms occur, consider referral to an ophthalmologist.
Monitoring Parameters
Monitor for signs of infection.
Pregnancy-Lactation
Pregnancy
There are no available data on topical betamethasone dipropionate or clotrimazole use in pregnant women to identify drug associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes; observational studies suggest an increased risk of low birth weight infants with use of potent or very potent topical corticosteroid during pregnancy
Advise pregnant women that therapy may increase risk of having a low birth weight infant and to use drug on the smallest area of skin and for shortest duration possible
Animal data
In an animal reproduction study, betamethasone dipropionate caused malformations (ie, umbilical hernias, cephalocele, and cleft palate) in pregnant rabbits when given by intramuscular route during organogenesis
The available data do not allow calculation of relevant comparisons between systemic exposure of clotrimazole and/or betamethasone dipropionate observed in animal studies to systemic exposure that would be expected in humans after topical use of drug
Lactation
Advise a woman to apply drug to smallest area of skin and for shortest duration possible while breastfeeding; advise breastfeeding women not to apply drug directly to nipple and areola to avoid direct infant exposure
Interactions
Contraindicated (2)
elagolix
lomitapide
Serious (11)
axitinib
bosutinib
eliglustat
entrectinib
everolimus
infigratinib (DSC)
lurbinectedin
midazolam intranasal
mobocertinib
nirogacestat
pacritinib
Adverse Effects
Side effects of Betamethasone 0.05% + Clotrimazole 1% Topical :
1-10%
Dry skin (2%),Paresthesia (2%),Local burning (2%)
<1%
Edema,Rash,Skin atrophy,Secondary infection,Skin ulceration,Acneiform eruption,Bruising,Folliculitis,Striae
Clotrimazole
Erythema,Stinging,Blistering,Peeling,Edema,Pruritus,Urticaria,General skin irritation
Betamethasone
Burning,Itching,Irritation,Dryness,Folliculitis,Hypertrichosis,Acneiform eruptions,Hypopigmentation,Perioral dermatitis,Allergic contact dermatitis,Skin maceration,Skin atrophy,Striae,Miliaria,HPA suppression (with higher potency used >2 wk)
Mechanism of Action
Betamethasone dipropionate is a corticosteroid that prevents and reduce inflammation by depressing the migration of polymorphonuclear leukocytes and fibroblasts; reversing capillary permeability and lysosomal stabilisation at the cellular level. Clotrimazole is an antifungal agent that binds to phospholipids in the fungal cell membrane. It causes loss of essential intracellular components by altering cell wall permeability.
Note
Bet Cl 0.05% + 1% Cream manufactured by Acme Laboratories Ltd.. Its generic name is Betamethasone 0.05% + Clotrimazole 1% Topical. Bet Cl is availble in Bangladesh.
Farmaco BD drug index information on Bet Cl Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.