Azobrin Ophthalmic Suspension
Brinzolamide 1% Eye prep
1%
Healthcare Pharmaceuticals Ltd.
| Pack size | 5 ml |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 500.00 AED |
Indications
Azobrin Ophthalmic Suspension is used for:
Open-angle glaucoma , ocular hypertension
Adult Dose
Adult:
Ophth Open-angle glaucoma; Ocular HTN
As 1% susp: Instill one drop in the affected eye(s) three times daily
Child Dose
Renal Dose
Administration
May be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure; if more than one topical ophthalmic drug being used, administer at least ten min apart
Contra Indications
Brinzolamide 1% ophthalmic suspension is contraindicated in patients who are hypersensitive to any component of this product.
Precautions
Sulfonamide hypersensitivity reactions
Corneal edema may occur in patients with low endothelial cell counts
Carbonic anhydrase activity has been observed in both the cytoplasm and around the plasma membranes of the corneal endothelium; there is an increased potential for developing corneal edema in patients with low endothelial cell counts; use caution when prescribing this medication to this group of patients
This medication has not been studied in patients with severe renal impairment [creatinine clearance (CrCl) less than 30 mL/min]; because the drug and its metabolite are excreted predominantly by the kidney, this drug is not recommended in such patients
The management of patients with acute angle-closure glaucoma requires therapeutic interventions in addition to ocular hypotensive agents; this medication has not been studied in patients with acute angle-closure glaucoma
Pregnancy-Lactation
Pregnancy
There are no adequate and well-controlled studies in pregnant women to inform drug-associated risk
In reproductive toxicity studies, brinzolamide administered orally to rats induced fetal toxicity at 375-times the recommended human ophthalmic dose (RHOD) based on mg/kg; in rabbits, no fetal toxicity was observed following oral administration
Lactation
There are no data on presence of brinzolamide in human milk, effects on breastfed infant, or on milk production; drug has been detected in the milk of lactating rats
The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for drug and any potential adverse effects on breast-fed child from drug
Interactions
Concurrent use w/ oral carbonic anhydrase inhibitors may lead to additive systemic effects.
Concurrent use w/ high-dose salicylates may lead to toxicity.
Adverse Effects
Side effects of Brinzolamide 1% Eye prep :
1-10%
Blurred vision (5-10%),Dysgeusia (5-10%),Blepharitis (1-5%),Dermatitis (1-5%),Dry eye (1-5%),Foreign body sensation (1-5%),Headache (1-5%),Hyperemia (1-5%),Ocular discharge (1-5%),Ocular discomfort (1-5%),Ocular keratitis (1-5%),Ocular pain (1-5%),Ocular pruritus (1-5%),Rhinitis (1-5%)
<1%
Allergic reactions,Alopecia,Chest pain,Conjunctivitis,Diarrhea,Diplopia,Dizziness,Dry mouth,Dyspnea,Dyspepsia,Eye fatigue,Hypertonia,Keratoconjunctivitis,Keratopathy,Kidney pain,Lid margin crusting or sticky sensation,Nausea,Pharyngitis,Tearing,Urticaria
Mechanism of Action
Brinzolamide is a carbonic anhydrase inhibitor that decreases secretion of aqueous humor thus reducing intraocular pressure.
Note
Azobrin 1% Ophthalmic Suspension manufactured by Healthcare Pharmaceuticals Ltd.. Its generic name is Brinzolamide 1% Eye prep. Azobrin is availble in Bangladesh.
Farmaco BD drug index information on Azobrin Ophthalmic Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.