Azin Eye Drops
Azithromycin 1% Eye drop
1 gm/100 ml
Acme Laboratories Ltd.
| Pack size | |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price |
Indications
Azin Eye Drops is used for:
Bacterial Conjunctivitis, Neonatal Conjunctivitis, Blepharitis
Adult Dose
Bacterial conjunctivitis
Adult: Instill 1 drop in the affected eye(s) bid for 2 days, then once daily for the next 5 days.
Child Dose
Bacterial conjunctivitis
Child >1 year: Instill 1 drop in the affected eye(s) bid for 2 days, then once daily for the next 5 days.
<1 years Safety & efficacy not established
Renal Dose
Administration
Contra Indications
Known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic. Coadministration w/ pimozide. History of cholestatic jaundice/hepatic dysfunction associated w/ prior use of azithromycin.
Precautions
Known hypersensitivity to azithromycin or erythromycin
Serious allergic reactions, including angioedema, anaphylaxis, and dermatologic reactions including Stevens Johnson Syndrome and toxic epidermal necrolysis have been reported; although rare, fatalities have been reported
If superinfection occurs or if clinical improvement not noted within 7 days, discontinue use and institute appropriate therapy; whenever clinical judgment dictates, the patient should be examined with the aid of magnification, such as slit-lamp biomicroscopy, and where appropriate, fluorescein staining
Therapy may result in overgrowth of nonsusceptible organisms including fungi
Avoid contact lens wear during therapy of S/S of bacterial conjunctivitis
Do not administer systemically; inject SC; or apply directly into anterior eye chamber
Avoid contaminating applicator tip by not allowing it to touch eye, fingers or other sources
Pregnancy-Lactation
Pregnancy
Available data from published literature and postmarketing experience over several decades with azithromycin use in pregnant women have not identified any drug-associated risks for major birth defects, miscarriage, or adverse maternal or fetal outcomes
Animal data
Developmental toxicity studies with azithromycin in rats, mice, and rabbits showed no drug-induced fetal malformations at doses up to 200 mg/kg/day; the doses used in these studies were orders of magnitude in excess of the clinical exposure that would be possible following topical ocular administration of azithromycin
Lactation
Azithromycin is present in human milk; non-serious adverse reactions reported in breastfed infants after maternal administration of oral azithromycin
There are no available data on the effects of this drug on milk production; the developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed infants from
Interactions
Adverse Effects
Side effects of Azithromycin 1% Eye drop :
1-10%
Eye irritation (1-2%)
<1%
Anaphylaxis,Contact dermatitis,Corneal erosion,Dry eye,Rash,Urticaria,Dygeusia,Nasal congestion,Ocular discharge,Punctate keratitis,Sinusitis
Mechanism of Action
Azithromycin is a semisynthetic azalide antibiotic. It blocks transpeptidation by binding to 50s ribosomal subunit of susceptible organisms and disrupting RNA-dependent protein synthesis at the chain elongation step.
Note
Azin 1 gm/100 ml Eye Drops manufactured by Acme Laboratories Ltd.. Its generic name is Azithromycin 1% Eye drop. Azin is availble in Bangladesh.
Farmaco BD drug index information on Azin Eye Drops is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.