Atenol Tablet
Atenolol
100 mg
Pharmadesh Laboratories Ltd.
| Pack size | 100's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 1.38 AED |
Available as:
Indications
Atenol Tablet is used for:
Hypertension, Migraine, Arrhythmias, MI, Angina pectoris
Adult Dose
Adult
Oral
Hypertension
25-50 mg/day initially; may be increased to 100 mg/day
Angina Pectoris
50 mg/day; after 1 week, may be increased to 100 mg/day; some patients may require 200 mg/day
Post Myocardial Infarction
Secondary prevention
100 mg PO once daily or divided q12hr for 6-9 days after myocardial infarction (MI)
Child Dose
Renal Dose
Renal impairment:
CrCl (ml/min)
<15 25 mg or 50 mg on alternate days.
15-35 50 mg/day.
Dialysis patients 25-50 mg after each dialysis.
Administration
May be taken with or without food.
Contra Indications
1. sinus bradycardia, or bradycardia of other origin
2. second and third-degree A-V block
3. sick sinus syndrome
4. right ventricular failure secondary to pulmonary hypertension
5. uncontrolled heart failure
6. cardiogenic shock
7. hypotension
8. severe peripheral arterial disorders
9. anesthesia with agents that produce myocardial depression
10. pheochromocytoma, in the absence of alpha-blockade
11. metabolic acidosis
12. known hypersensitivity to the product
Precautions
Ischemic heart disease may be exacerbated after abrupt withdrawal
Hypersensitivity to catecholamines has been observed during withdrawal
Exacerbation of angina and, in some cases, MI may occur after abrupt discontinuance
When long-term beta blocker therapy (particularly with ischemic heart disease) is discontinued, dosage should be gradually reduced over 1-2 weeks with careful monitoring
If angina worsens markedly or acute coronary insufficiency develops, beta-blocker administration should be promptly reinitiated, at least temporarily (in addition to other measures appropriate for unstable angina)
Patients should be warned against interruption or discontinuance of beta-blocker therapy without physician advice
Because coronary artery disease (CAD) is common and may be unrecognized, beta-blocker therapy must be discontinued slowly, even in patients treated only for hypertension
General: Patients already on a beta blocker must be evaluated carefully before Atenolol is administered.
Initial and subsequent Atenolol dosages can be adjusted downward depending on clinical observations including pulse and blood pressure. Atenolol may aggravate peripheral arterial circulatory disorders.
Impaired Renal Function: The drug should be used with caution in patients with impaired renal function.
Geriatric Use: Hypertension and Angina Pectoris Due to Coronary Atherosclerosis:
Dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic,
renal, or cardiac function, and of concomitant disease or other drug therapy.
Acute Myocardial Infarction: Dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Evaluation of patients with hypertension or myocardial infarction should always include an assessment of renal function.
Pregnancy-Lactation
Pregnancy category: D
Lactation: Drug enters breast milk; neonates born to mothers who are receiving atenolol at parturition or breastfeeding may be at risk for hypoglycemia and bradycardia; use with caution
Interactions
Catecholamine-depleting drugs (eg, reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with Atenolol plus a catecholamine depletor should therefore be closely observed for evidence of hypotension and/or marked bradycardia which may produce vertigo, syncope, or postural hypotension.
Calcium channel blockers may also have an additive effect when given with Atenolol.
Disopyramide is a Type I antiarrhythmic drug with potent negative inotropic and chronotropic effects. Disopyramide has been associated with severe bradycardia, asystole and heart failure when administered with beta-blockers.
Amiodarone is an antiarrhythmic agent with negative chronotropic properties that may be additive to those seen with beta-blockers.
Beta blockers may exacerbate the rebound hypertension which can follow the withdrawal of clonidine. If the two drugs are coadministered, the beta blocker should be withdrawn several days before the gradual withdrawal of clonidine. If replacing clonidine by beta-blocker therapy, the introduction of beta-blockers should be delayed for several days after clonidine administration has stopped.
Concomitant use of prostaglandin synthase inhibiting drugs, eg, indomethacin, may decrease the hypotensive effects of beta blockers.
While taking beta-blockers, patients with a history of anaphylactic reaction to a variety of allergens may have a more severe reaction on repeated challenge, either accidental, diagnostic or therapeutic. Such patients may be unresponsive to the usual doses of epinephrine used to treat the allergic reaction.
Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia.
Contraindicated (0)
Serious - Use Alternative (24)
acebutolol
betaxolol
bisoprolol
carvedilol
celiprolol
clonidine
digoxin
diltiazem
esmolol
fexinidazole
labetalol
lofexidine
mavacamten
metoprolol
nadolol
nebivolol
penbutolol
pindolol
propranolol
rivastigmine
saquinavir
sotalol
timolol
verapamil
Adverse Effects
Side effects of Atenolol :
>10%
Tiredness (13%)
1-10%
Hypotension (10%),Bradycardia (8%),Cold extremities (0.5- 7%),Postural hypotension (2-4%),Depression (3%),Nausea (2-3%),Dreaming (2%),Drowsiness (2%),Diarrhea (1-2%),Fatigue (1-2%),Leg pain (1-2%),Lethargy (1-2%),Lightheadedness (1-2%),Vertigo (1-2%),Dyspnea (0.4-2%),2°/3° atrioventricular (AV) block (1%)
Frequency Not Defined
Hypotension, severe congestive heart failure (CHF), sick sinus syndrome, Catatonia, disorientation, emotional lability, hallucinations, headache, impaired performance on neuropsychometric tests, psychoses, short-term memory impairment, Purpura, rashes,Nausea, Thrombocytopenia, Elevated serum hepatic enzymes and bilirubin, Impotence, Peyronie disease, Antinuclear antibodies (ANA), lupus syndrome, Visual disturbances, xerophthalmia, Raynaud phenomenon
Potentially Fatal: Heart failure, 2nd or 3rd degree AV block.
Mechanism of Action
Atenolol is a competitive cardioselective beta1-blocker and does not have effect on ?beta2-receptors except in high doses. It reduces resting and exercise-induced heart rate as well as myocardial contractility.
Note
Atenol 100 mg Tablet manufactured by Pharmadesh Laboratories Ltd.. Its generic name is Atenolol. Atenol is availble in Bangladesh.
Farmaco BD drug index information on Atenol Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.