Artex Tablet
Artesunate
50mg
Jayson Pharmaceuticals Ltd.
| Pack size | 12's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 12.08 AED |
Indications
Artex Tablet is used for:
Malaria, Schistosomiasis
Adult Dose
Falciparum malaria especially in quinidine-resistant patients
Adult:
Artesunate 50 mg
2 tablets twice on the first day
1 tablet twice daily for the next four days
Child Dose
Children:
Artesunate 50 mg
1 tablet, taken twice on the first day
1 tablet daily for the subsequent days
Children:
1-3 years: 3 Artesunate 50 mg tablets for 5 days
4-5 years: 6 Artesunate 50 mg tablets for 5 days
6-12 years: 8 Artesunate 50 mg tablets for 5 days
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Hepatic or renal insufficiency. Pregnancy and lactation.
Pregnancy-Lactation
Pregnancy
May administered to pregnant women in the second and third trimesters
Data are limited for the first trimester of pregnancy; no harmful effects have been observed
Animal studies
Causes fetal toxicity in rats and rabbits resulting in fetal resorption and abortion
Low incidence of cardiac malformations and skeletal defects was also observed
Clinical considerations
Severe malaria is life-threatening for pregnant women and their fetuses, and artesunate should not be withheld if quinidine is unavailable, contraindicated, ineffective, and/or not tolerated
Lactation
Limited distribution into human breast milk
LactMed states limited information indicates that a maternal dose of 200 mg PO produced low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if aged >2 months
Withholding breastfeeding for 6 hr after the dose should markedly reduce the amount infant receives
Interactions
Antimalarial potentiating action seen with mefloquine, primaquine and tetracycline. Additive effect with chloroquine. Antagonistic effect with pyrimethamine and sulphonamides.
Adverse Effects
Side effects of Artesunate :
Generally well-tolerated, Cardiotoxicity (high doses), Neurotoxicity observed in animal studies, Drug induced fever, Skin rash
Mechanism of Action
Artesunate is a potent and rapidly-acting blood schizontocide derived from the leaves of the chinese herb, Armesia annua. The exact mode of action is not clear but clinical studies have confirmed the effectiveness of artesunate in P. vivax and falciparum malaria. Unclear, may inhibit DNA replication & transcription.
Note
Artex 50mg Tablet manufactured by Jayson Pharmaceuticals Ltd.. Its generic name is Artesunate. Artex is availble in Bangladesh.
Farmaco BD drug index information on Artex Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.