Arocaine-A DC Injection
Articaine Hydrochloride + Epinephrine
4 gm + 1 mg/100 ml
Jayson Pharmaceuticals Ltd.
| Pack size | 5's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 48.33 AED |
Indications
Arocaine-A DC Injection is used for:
Local anesthesia in Dental Procedures
Adult Dose
Local, Infiltrative, or Conductive Anesthesia in Dental Procedures
Infiltration: 0.5-2.5 mL injection of 4% solution; 20-100 mg total dose
Nerve block: 0.5-3.4 mL injection of 4% solution; 20-136 mg total dose
Oral surgery: 1-5.1 mL injection of 4% solution; 40-204 mg total dose
Not to exceed 7 mg/kg (0.175 mL/kg)
Child Dose
Local, Infiltrative, or Conductive Anesthesia in Dental Procedures
<4 years old: Safey and efficacy not established
4-16 years old: Use lower end of dose range
No more than 7 mg/kg (0.175 mL/kg)
Renal Dose
Administration
Contra Indications
Tachycardia, hypertension, cerebral arteriosclerosis, ischaemic heart disease, IV admin, anaesthetise digits or appendages, myasthenia gravis.
Precautions
Accidental Intravascular Injection: May be associated with convulsions followed by coma and respiratory arrest. Resuscitative equipment, oxygen and other resuscitative drugs should be available.
Systemic Toxicity: Systemic absorption of Articaine + Epinephrine can produce effects on the central nervous and cardiovascular systems.
Vasoconstrictor Toxicity: Local anesthetic solutions like Articaine + Epinephrine that contain a vasoconstrictor should be used cautiously, especially in patients with impaired cardiovascular function or vascular disease.
Methemoglobinemia: Cases of methemoglobinemia have been reported in association with local anesthetic use.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown; use with caution
Interactions
Monoamine Oxidase Inhibitors, Nonselective Beta-Adrenergic Antagonists, or Tricyclic Antidepressants: May produce severe, prolonged hypertension.
Phenothiazines and Butyrophenones: May reduce or reverse the pressor effect of epinephrine.
Concurrent use of these agents should be avoided; however, in situations when concurrent therapy is necessary, careful patient monitoring is essential.
Contraindicated (15)
disopyramide
ibutilide
indapamide
iobenguane I 123
isocarboxazid
linezolid
lurasidone
pentamidine
phenelzine
pimozide
procainamide
quinidine
selegiline transdermal
sotalol
tranylcypromine
Adverse Effects
Side effects of Articaine Hydrochloride + Epinephrine :
1-10%
Facial edema,Headache,Pain,Paresthesia,Sleepiness,Gingivitis,Nausea,Vomiting,Infection
Frequency Not Defined
Systemic absorption of significant concentrations of local anesthetic can produce myocardial depression, cardiac conduction changes, CNS excitation, convulsions, and cardiorespiratory arrest
Potentially Fatal: CNS toxicity (due to inadvertent IV admin), medullary depression with tonic & clonic convulsions; ventricular fibrillation; severe hypertension with cerebral haemorrhage and pulmonary oedema; unconsciousness; possibly respiratory arrest. Allergic reactions including anaphylactic symptoms and possibly life threatening asthmatic episodes in susceptible patients may occur due to sodium metabisulphate constituent. Central nerve blocks may cause CV depression (especially in hypovolaemia). Retrobulbar inj may reach subarachnoid space causing CV collapse, apnoea, convulsions, temporary blindness. Paracervical block may cause foetal bradycardia/tachycardia (careful monitoring of foetal heart rate is necessary).
Mechanism of Action
Local anesthetics prevent generation/conduction of nerve impulses by reducing sodium permeability and increasing action potential threshold.
Note
Arocaine-A DC 4 gm + 1 mg/100 ml Injection manufactured by Jayson Pharmaceuticals Ltd.. Its generic name is Articaine Hydrochloride + Epinephrine. Arocaine-A DC is availble in Bangladesh.
Farmaco BD drug index information on Arocaine-A DC Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.