Aristobet Cream
Betamethasone valerate 0.1% Topical
100mg
Aristopharma Limited
| Pack size | 20 gm |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 44.00 AED |
Available as:
Indications
Aristobet Cream is used for:
Lichen planus, Psoriasis, Eczema, Contact dermatitis, Systemic lupus erythematosus, Lichen simplex, Prurigo nodularis, Plaque psoriasis.
Adult Dose
Topical
For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
As valerate: Apply sparingly 2-3 times daily.
Cream for moist & ointment for dry surface.
Child Dose
Topical
For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
<12 years: Not recommended
>12 years: Apply ointment once or three times daily
Renal Dose
Administration
Topical Administration
Use medium to very high potency for less than 2 weeks to reduce local and systemic side effects
Use low potency for chronic therapy
Avoid medium to very high potency on face, folds, and groin, because use in these areas can increase steroid absorption
Use lower potency for children (ie, increased BSA/kg, therefore increased systemic absorption)
Contra Indications
Hypersensitivity; systemic fungal or acute infections.
Precautions
Chronic topical corticosteroid therapy may interfere with growth and development in children
Prolonged treatment with corticosteroids is associated with Kaposi sarcoma (consider discontinuation of therapy if diagnosed)
Discontinue if contact dermatitis occurs; not for use in patients with decreased skin circulation
Manifestations of Cushing syndrome, hyperglycemia, or glycosuria occur, especially if occlusive dressings are used
May increase risk of posterior subcapsular cataracts and glaucoma; cataracts and glaucoma reported postmarketing with use of topical corticosteroid products, including ointment
Use may increase the risk of posterior subcapsular cataracts and glaucoma; avoid contact with eyes; advise patients to report any visual symptoms and consider referral to an ophthalmologist for evaluation
Pregnancy-Lactation
Pregnancy
There are no available data on ointment use in pregnant women to identify a drug- associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes; observational studies suggest an increased risk of low birthweight infants with the use of greater than 300 grams of potent or very potent topical corticosteroid during a pregnancy; advise pregnant women that the ointment may increase risk of having a low birthweight infant and to use it on the smallest area of skin and for the shortest duration possible
Animal data
In animal reproduction studies, increased malformations, including umbilical hernias, cephalocele, and cleft palate, were observed after intramuscular administration to pregnant rabbits; the available data do not allow calculation of relevant comparisons between systemic exposure in animal studies to systemic exposure that would be expected in humans after topical use of the ointment
Lactation
There are no data regarding the presence of drug in human milk, effects on breastfed infant, or on milk production after topical ointment application to women who are breastfeeding
It is possible that topical administration of betamethasone dipropionate could result in sufficient systemic absorption to produce detectable quantities in human milk; the developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for therapy and any potential adverse effects on breastfed infant drug or from underlying maternal condition
To minimize potential exposure to breastfed infant via breast milk, use ointment on smallest area of skin and for shortest duration possible while breastfeeding; advise breastfeeding women not to apply ointment directly to nipple and areola to avoid direct infant exposure
Interactions
Adverse Effects
Side effects of Betamethasone valerate 0.1% Topical :
Frequency Not Defined
Skin atrophy
Striae
Allergic dermatitis
Burning
Dry skin
Erythema folliculitis
Hypertrichosis
Irritation
Miliaria
Vesiculation
Acneform lesions
Pigmentation changes
HPA suppression (with higher potency used >2 wk)
Mechanism of Action
Betamethasone is a corticosteroid with mainly glucocorticoid activity. It prevents and controls inflammation by controlling the rate of protein synthesis, depressing the migration of polymorphonuclear leukocytes and fibroblasts, and reversing capillary permeability and lysosomal stabilisation.
Note
Aristobet 100mg Cream manufactured by Aristopharma Limited. Its generic name is Betamethasone valerate 0.1% Topical. Aristobet is availble in Bangladesh.
Farmaco BD drug index information on Aristobet Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.