Antrenex Tablet
Oxyphenonium Bromide
5mg
Opsonin Pharma Limited
| Pack size | 100's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 1.25 AED |
Indications
Antrenex Tablet is used for:
Peptic ulcer, Gastrointestinal tract spasm, Visceral spasms
Adult Dose
Adults: 1-2 tablets 3-4 times daily.
Child Dose
Children: 1/2-1 tablet 1-3 times daily.
Renal Dose
Administration
Contra Indications
Urinary outflow obstruction, paralytic ileus, myasthenia gravis.
Precautions
Children; elderly; benign prostatic hyperplasia; acute MI, cardiac failure, hypertension, thyrotoxicosis; pregnancy and lactation; fever; angle-closure glaucoma.
Pregnancy-Lactation
Interactions
Reduced gastric motility interferes with absorption of other drugs. Effects potentiated by other antimuscarinics including amantadine, some antihistamines, phenothiazines and TCA.
Adverse Effects
Side effects of Oxyphenonium Bromide :
Dryness of mouth, difficulty in talking/swallowing; reduced bronchial secretions; blurring of vision, photophobia; bradycardia followed by tachycardia and arrhythmias; urinary retention, constipation, vomiting, nausea; confusion and giddiness.
Potentially Fatal: Arrhythmias (especially after MI).
Mechanism of Action
Oxyphenonium is an anticholinergic drug. It exerts its action by inhibiting muscarinic (cholinergic) receptors on smooth muscles, cardiac muscles and prevents the effect of Acetylcholine. Inhibition of Acetylcholine produces relaxation of smooth muscles and prevents the muscle spasm in irritable bowel syndrome.
Oxyphenonium also has a direct relaxant effect on smooth muscle. It also inhibits gastrointestinal propulsive movement and decreases gastric acid secretion and control bronchial, pharyngeal and tracheal secretions. It also possesses nicotinic blocking activity and interferes with ganglionic or neuromuscular transmission. It cross the BBB poorly and does not produce CNS effect.
Note
Antrenex 5mg Tablet manufactured by Opsonin Pharma Limited. Its generic name is Oxyphenonium Bromide. Antrenex is availble in Bangladesh.
Farmaco BD drug index information on Antrenex Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.