Amit Tablet
Amitriptyline Hydrochloride
25mg
General Pharmaceuticals Ltd.
| Pack size | 100's Pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 1.76 AED |
Available as:
Indications
Amit Tablet is used for:
Migraine headache, Depression, Neuropathic pain, Post-herpetic neuralgia, Nocturnal enuresis
Adult Dose
Adult: PO
Depression Initial:50-75 mg/day; up to 150 mg/day if needed.
Max: 300 mg/day in severe cases.
Neuropathic pain Initial: 10-25 mg/day at night, up to 75 mg/day if needed.
Migraine prophylaxis Initial: 10 mg/day at night. Maintenance: 50-75 mg/day at night.
Child Dose
PO
Depression
Child: Adolescent: Initially, 25-50 mg/day as a single dose (at bedtime) or in divided doses.
Nocturnal enuresis
Child: 6-10 yr 10-20 mg/day; 11-16 yr 25-50 mg/day. All doses to be given at bedtime.
Max duration: 3 mth.
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity, use of MAO inhibitors within the last 14 days; acute recovery phase post-MI. Concurrent usage with cisapride.
Precautions
In short-term studies, antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults (<24 years) taking antidepressants for major depressive disorders and other psychiatric illnesses; this increase was not seen in patients over age 24 years; a slight decrease in suicidal thinking was seen in adults over age 65 years
In children and young adults, the risks must be weighed against the benefits of taking antidepressants
Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during the initial 1-2 months of therapy and dosage adjustments; the patient’s family should communicate any abrupt changes in behavior to the healthcare provider
Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy
This drug is not approved for use in pediatric patients <12 years
Not FDA-approved for treatment of bipolar depression
Bone marrow suppression reported
Avoid use in narrow-angle glaucoma
May cause sedation and impair mental and physical abilities
Avoid use with any drugs or conditions that prolong QT interval
May cause orthostatic hypotension
Use caution in patients with cardiovascular disease, diabetes, mania, hepatic and renal impairment, thyroid dysfunction, and seizure disorder
May worsen mania symptoms or precipitate mania in patients with bipolar disorder
Clinical worsening and suicidal ideation may occur despite medication in adolescents and young adults (18-24 years)
Risk of anticholinergic side effects; may cause constipation, urinary retention, blurred vision, and xerostomia
Use caution in patients with urinary retention, open-angle glaucoma, BPH, decreased gastrointestinal motility, or paralytic ileus
Possibility of EPS and neuroleptic malignant syndrome
Abrupt discontinuation of therapy not recommended in patients receiving high doses for prolonged periods
Fractures reported with therapy
Monitoring Parameters
Monitor for signs of clinical worsening, suicidality, or behavioral changes.
Pregnancy-Lactation
Pregnancy category: C
Lactation: Distributed in breast milk; do not nurse (AAP states effect on nursing infants is unknown but may be of concern)
Interactions
Increased risk of serotonin syndrome w/ SSRIs, TCAs, triptans, fentanyl, lithium, tramadol. May reduce plasma levels w/ barbiturates, rifampicin and other anticonvulsants. May increase plasma levels w/ methylphenidate, cimetidine, antipsychotics, Ca channel blockers. May precipitate cardiac arrhythmias w/ thyroid hormones. May reduce antihypertensive effects of debrisoquine, guanethidine and clonidine. May increase pressor effect of epinephrine and norepinephrine. May increase the risk of ventricular arrhythmias w/ antiarrhythmics (e.g. amiodarone or quinidine), antihistamines astemizole, terfenadine, some antipsychotics (pimozide, sertindole, and thioridazine), sotalol, cisapride and halofantrine.
Potentially Fatal: Increased risk of serotonin syndrome w/ MAOIs, linezolid and methylene blue.
Contraindicated (17)
disopyramide
dronedarone
ibutilide
indapamide
iobenguane I 123
isocarboxazid
mavorixafor
pentamidine
phenelzine
pimozide
procainamide
procarbazine
quinidine
safinamide
selegiline
sotalol
tranylcypromine
Adverse Effects
Side effects of Amitriptyline Hydrochloride :
Frequency Not Defined
Agitation
Agranulocytosis
Alopecia
Anxiety
Anorexia
Ataxia
Arrhythmia
Blurred vision
Coma
Confusion
Constipation
Diarrhea
Dizziness
Dry mouth
ECG changes
Eosinophilia
Extrapyramidal symptoms (EPS)
Fatigue
Hallucination
Headache
Hypertension
Increased LFTs
Insomnia
Lethargy
Leukopenia
MI
Nausea
Ocular pressure increased
Orthostatic hypotension
Palpitation
Paresthesia
Photosensitivity
Rash
Restlessness
Sedation
Seizure
Sexual dysfunction
SIADH
Stroke
Stomatitis
Syncope
Sweating
Tachycardia
Thrombocytopenia
Tinnitus
Urinary retention
Urticaria
Vomiting
Xerostomia
Weakness
Weight gain
Potentially Fatal: Cardiac arrhythmias.
Mechanism of Action
Amitriptyline is a dibenzocycloheptadiene tricyclic antidepressant. It increases synaptic concentration of serotonin and/or norepinephrine in the CNS by blocking the neuronal reuptake of norepinephrine and serotonin.
Note
Amit 25mg Tablet manufactured by General Pharmaceuticals Ltd.. Its generic name is Amitriptyline Hydrochloride. Amit is availble in Bangladesh.
Farmaco BD drug index information on Amit Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.