Ametrol VT Vaginal Tablet
Metronidazole + Miconazole Nitrate Vag prep
100 mg+100 mg
Ambee Pharmaceuticals Ltd.
| Pack size | 10's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 11.04 AED |
Indications
Ametrol VT Vaginal Tablet is used for:
Vaginal candidiasis, Bacterial and trichomonal vaginitis
Adult Dose
Adult: Vag candidiasis: 100 mg every night for 7-14 days.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity; hepatic impairment (oral gel). Porphyria.
Precautions
For external use only; discontinue if sensitization or irritation occurs. Pregnancy and lactation
Pregnancy-Lactation
Interactions
Metronidazole: Disulfiram-like reaction w/ alcohol. Increased oral anticoagulant effect, blood levels of phenytoin, lithium toxicity, plasma conc of astemizole & terfenadine; blood conc of carbamazepine. Decreased blood levels w/ phenobarb. Risk of CNS-related effects (eg psychotic reactions) w/ disulfiram. Increased blood levels & neurologic effects w/ cimetidine. May increase blood levels & toxicity of fluorouracil; toxicity of cyclosporine. Increased cardiotoxicity w/ amiodarone. Interference w/ blood levels of liver enzymes, glucose (hexokinase method), theophylline & procainamide. Decreased levels w/ phenytoin.
Miconazole: Increased risk of bleeding w/ acenocoumarol, anisindione, dicumarol, phenindione, phenprocoumon, warfarin; plasma conc & exposure to oxybutinin. May increase risk of phenytoin, phosphenytoin, cyclosporine, trimetrexate toxicity & cardiotoxicity w/ pimozide. May inhibit metabolism of astemizole, cisapride & terfenadine. Reduced carbamazepine metabolism. Increased or prolonged effects of opioid (fentanyl). May cause hypoglycemia w/ glimepiride. Reduced clearance & increased plasma conc of oxycodone. May increase bioavailability of tolterodine (in patients w/ deficient CYP2D6 activity).
Adverse Effects
Side effects of Metronidazole + Miconazole Nitrate Vag prep :
Nausea, vomiting, febrile reactions, rash, drowsiness, diarrhoea, anorexia and flushing, hepatitis. Local irritation and sensitisation, contact dermatitis.
Mechanism of Action
Metronidazole is converted to reduction products that interact w/ DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms. It is active against most anaerobic protozoa, some gm+ve, gm-ve and facultative anaerobes.
Miconazole inhibits ergosterol synthesis thus damaging fungal cell wall membrane and increases its permeability, allowing leakage of nutrients.
Note
Ametrol VT 100 mg+100 mg Vaginal Tablet manufactured by Ambee Pharmaceuticals Ltd.. Its generic name is Metronidazole + Miconazole Nitrate Vag prep. Ametrol VT is availble in Bangladesh.
Farmaco BD drug index information on Ametrol VT Vaginal Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.