Alistin Dispersible Tablet
Acetylcysteine
600 mg
Opsonin Pharma Limited
| Pack size | 30's Pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 15.00 AED |
Available as:
Indications
Alistin Dispersible Tablet is used for:
Tuberculosis, Chronic emphysema, Paracetamol poisoning, Bronchiectasis, Pneumonia, Atelectasis, Cystic fibrosis, Tracheostomy care, during anaesthesia
Adult Dose
Oral
As a mucolytic
Adult: As effervescent granules or tablets: 200 mg tid.
Paracetamol poisoning
Adult: After gastric lavage or induction of emesis with ipecac syrup, admin loading dose of 140 mg/kg, followed by maintenance doses of 70 mg/kg every 4 hr for a total of 17 doses.
1st maintenance dose to be given 4 hr after the loading dose. Repeat dose if the patient vomits within 1 hr of admin. Continue therapy until paracetamol levels are not detectable and there is no evidence of hepatotoxicity.
Inhalation
As a mucolytic
Adult: 3-5 ml of a 20% solution or 6-10 ml of a 10% solution 3-4 times daily by nebulizing through a face mask, mouthpiece or tracheostomy. May increase to 1-10 ml of a 20% solution or 2-20 ml of a 10% solution every 2-6 hr if needed.
Endotracheal
As a mucolytic
Adult: Instill 1-2 ml of a 10-20% solution as often as every hrly.
Child Dose
Oral
As a mucolytic
Child: As effervescent granules or tablets: 2-7 yr: 200 mg bid; <2 yr: 200 mg daily.
Paracetamol poisoning
Child: After gastric lavage or induction of emesis with ipecac syrup, admin loading dose of 140 mg/kg, followed by maintenance doses of 70 mg/kg every 4 hr for a total of 17 doses. 1st maintenance dose to be given 4 hr after the loading dose. Repeat dose if the patient vomits within 1 hr of admin. Continue therapy until paracetamol levels are not detectable and there is no evidence of hepatotoxicity.
Inhalation
As a mucolytic
Child: 3-5 ml of a 20% solution or 6-10 ml of a 10% solution 3-4 times daily by nebulising through a face mask, mouth piece or tracheostomy. May increase to 1-10 ml of a 20% solution or 2-20 ml of a 10% solution every 2-6 hr if needed.
Endotracheal
As a mucolytic
Child: Instill 1-2 ml of a 10-20% solution as often as every hrly.
Renal Dose
Administration
Oral Preparation
Powder for oral solution
Dissolve the appropriate number of 2.5 g and/or 500 mg powder packets in the volume of caffeine-free diet cola or other diet soft drink, as indicated in dosing tables based on patient weight
Volume of liquid based on patient weight
1-19 kg: Dissolve 5 grams in 100 mL of water
20-59 kg: Dissolve dose in 150 mL of caffeine-free diet soft drink
>60 kg: Dissolve dose in 300 mL of caffeine-free diet soft drink
IV Preparation
Acetylcysteine is hyperosmolar (2600 mOsm/L) must be diluted with D5W, 0.45% NaCl injection, or sterile water for injection
Dilution in these 3 solutions results in different osmolarity of the solution for IV administration
IV Administration
300 mg/kg IV given as 3 separate, sequential doses (ie, 3-bag method to administer the loading, second, and third doses)
Total recommended infusion time for 3 doses is 21 hr
Contra Indications
Acetylcysteine is contraindicated in those patients who are sensitive to it.
Precautions
Use with caution in patients with asthma or history of bronchospasm; these patients are at increased risk of hypersensitivity reactions.
Peptic ulceration. Pregnancy, lactation.
Pregnancy-Lactation
Pregnancy category: B
Lactation: Unknown whether agent is excreted in milk; use with caution
Interactions
Drug stability and safety of acetylcysteine when mixed with other drugs in a nebulizer have not been established.
Adverse Effects
Side effects of Acetylcysteine :
Frequency Not Defined
Oral administration
Nausea
Vomiting
Drowsiness
Chills
Fever
IV administration
Anaphylactoid reaction due to pyrogens
Flushing
Edema
Urticaria
Pruritus
Nausea
Pharyngitis
Rhinorrhea
Inhalation administration
Bronchoconstriction
Bronchospasm
Calmness
Chest tightness
Disagreeable odor
Drowsiness
Fever
Hemoptysis
Increased volume of bronchial secretions
Irritation of tracheal or bronchial tract
Nausea
Rhinorrhea
Stomatitis
Vomiting
Potentially Fatal: Rarely, respiratory or cardiac arrest.
Mechanism of Action
Acetylcysteine may decrease the viscosity of secretions by splitting of disulphide bonds in mucoproteins. It also promotes the detoxification of an intermediate paracetamol metabolite which is used in the management of paracetamol overdosage.
Note
Alistin 600 mg Dispersible Tablet manufactured by Opsonin Pharma Limited. Its generic name is Acetylcysteine. Alistin is availble in Bangladesh.
Farmaco BD drug index information on Alistin Dispersible Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.
Some other brands of Acetylcysteine :
Effervescent Granules
Viscotin
100mg
UniMed UniHealth Pharmaceuticals Ltd.
Effervescent Granules
Viscotin
200mg
UniMed UniHealth Pharmaceuticals Ltd.
Effervescent Tablet
Viscotin
600mg
UniMed UniHealth Pharmaceuticals Ltd.
DT Tablet
Mucomist
600mg
Beximco Pharmaceuticals Ltd.
Inhalation Solution
Mucomist
600 mg/3 ml
Beximco Pharmaceuticals Ltd.