Adinir Powder for Suspension
Cefdinir
125mg/5ml
Acme Laboratories Ltd.
| Pack size | 60ml bot |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 175.66 AED |
Available as:
Indications
Adinir Powder for Suspension is used for:
Community-acquired pneumonia, Susceptible infections, Sinusitis, Otitis media, Sore throat, Soft tissue infections, Respiratory tract infections, Acute Exacerbations of Chronic bronchitis, Acute Maxillary Sinusitis
Adult Dose
Community-Acquired Pneumonia, Skin/Skin Structure Infections
300 mg PO q12hr for 10 days
Respiratory Tract Infections, Acute Maxillary Sinusitis
300 mg PO q12hr or 600 mg PO q24hr for 10 days
Child Dose
<6 months: Safety and efficacy not established
6 months-12 years: 7 mg/kg PO q12hr for 5-10 days or 14 mg/kg PO q24hr for 10 days
>12 years or >43 kg: 300 mg PO q12hr or 600 mg PO q24hr for 10 days
Renal Dose
Renal impairment
CrCl <30 mL/min (adults): Not to exceed 300 mg/day PO
CrCl <30 mL/min (children): 7 mg/kg PO q24hr; not to exceed 300 mg/day
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity.
Precautions
Note differences between twice-daily and once-daily dosing regimens
Use with caution in patients with history of penicillin allergy; if allergic reaction to cefdinir occurs, discontinue therapy
Dosage adjustments may be necessary if CrCl is <30 mL/min
Bacterial or fungal overgrowth of nonsusceptible organisms may occur with prolonged or repeated therapy
Use caution in patients with history of colitis
Antacids containing magnesium or aluminum interfere with absorption of cefdinir; if this required during therapy, administer at least 2 hr before or after antacid
Iron supplements, including multivitamins that contain iron, interfere with absorption of cefdinir; if iron supplements required administer at least 2 hours before or after supplement
Pregnancy-Lactation
Pregnancy category: B
Lactation: Unknown whether drug is excreted in milk
Interactions
Concomitant admin w/ antacids or Fe supplements reduce the rate and extent of absorption.
Admin w/ Fe supplements may cause reddish stools.
Decreased renal elimination w/ probenecid.
Contraindicated (0)
Serious (3)
BCG vaccine live
cholera vaccine
microbiota oral
Adverse Effects
Side effects of Cefdinir :
>10%
Diarrhea (8-15%)
1-10%
Vaginal moniliasis (<4%),Nausea (3%),Rash (3%),Headache (2%),Increased urine leukocytes (2%),Increased urine protein (1-2%),Decreased lymphocytes (1%),Glycosuria (1%),Increased alkaline phosphatase (1%),Increased eosinophils (1%),Increased platelets (1%)
Potentially Fatal: Anaphylaxis; renal and hepatic failure.
Mechanism of Action
Cefdinir binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Note
Adinir 125mg/5ml Powder for Suspension manufactured by Acme Laboratories Ltd.. Its generic name is Cefdinir. Adinir is availble in Bangladesh.
Farmaco BD drug index information on Adinir Powder for Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.