Acnev Cream
Clascoterone topical
1% w/w
ACI Limited
| Pack size | 10 gm tube |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 850.00 AED |
Indications
Acnev Cream is used for:
Acne Vulgaris
Adult Dose
Acne Vulgaris
Indicated for acne vulgaris
Apply thin layer topically to affected area BID
Child Dose
Acne Vulgaris
Indicated for acne vulgaris in patients aged >12 years
<12 years: Safety and efficacy not established
>12 years: Apply thin layer topically to affected area BID
Renal Dose
Administration
Gently cleanse the affected area; after the skin is dry, apply thin, uniform layer of cream to the affected area(s) twice per day (morning and evening)
For topical use only; not for ophthalmic, oral, or vaginal use
Contra Indications
Precautions
May induce local irritation (eg, erythema, redness, pruritus, scaling, dryness); limit concomitant use with other potentially irritating topical products that have a strong drying effect or have high concentrations of alcohol, astringents, spices, or lime
Pregnancy-Lactation
Pregnancy
No data are available on use in pregnant females to evaluate for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes
Animal studies
Subcutaneous administration to pregnant rats and rabbits during organogenesis at doses 8 or 39 times the maximum recommended human dose, respectively, increased malformations in rats and postimplantation loss and resorptions in rabbits
Lactation
Data are not available regarding presence of clascoterone or metabolite in human milk, effects on breastfed infants, or effects on milk production
Interactions
Adverse Effects
Side effects of Clascoterone topical :
>10%
Adverse effects listed below for the drug were similar to those for the vehicle cream in clinical trials
Erythema/redness (12.2%)
Scaling/dryness (10.5%)
1-10%
Adverse effects listed below for the drug were similar to those for the vehicle cream in clinical trials
Pruritus (7.7%)
Stinging/burning (4.2%)
Edema (3.6%)
Striae rubrae (2.5%)
Skin atrophy (1.6%)
Telangiectasia (1.2%)
Frequency Not Defined
Metabolism: Hyperkalemia
Reproductive: Polycystic ovaries, amenorrhea
Mechanism of Action
Exact mechanism of action is unknown; laboratory studies suggest clascoterone competes with androgens, specifically dihydrotestosterone, for binding to the androgen receptors within the sebaceous gland and hair follicles
Note
Acnev 1% w/w Cream manufactured by ACI Limited. Its generic name is Clascoterone topical. Acnev is availble in Bangladesh.
Farmaco BD drug index information on Acnev Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.