A Clox Powder for Suspension
Cloxacillin
125mg/5ml
Acme Laboratories Ltd.
| Pack size | 50ml bot |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 44.97 AED |
Indications
A Clox Powder for Suspension is used for:
Staphylococcal infections resistant to benzylpenicillin
Adult Dose
Oral
Adult: 250-500 mg 4 times/day.
Parenteral
Adults: 250 to 500 mg i.m. or i.v. every 6 hours.
For more severe infections (e.g. meningitis, endocarditis), 2 g 4 hrly.
The maximum dosage for adults is 6 g/day.
Child Dose
Oral
Child: 50-100 mg/kg in divided doses every 6 hr.
Up to 5 kg (11 lb) body weight: 250 mg/day.
Over 5 kg (11 lb) up to approximately 40 kg (85 lb) body weight: 50 mg/kg/day.
Total daily dosage must be divided into 4 doses, 1dose given every 6 hours.
In infections associated with streptococcus pyogenes, treatment should be continued for at least 10 days to reduce the risk of glomerulonephritis or rheumatic fever.
Parenteral
Children (up to 20 kg):
25 to 50 mg/kg/day into 4 equal doses administered i.m. or i.v. every 6 hours.
Renal Dose
Renal Impairment
Not studied; total dosage reduction should be considered
Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Reconstitution: IM: The contents of each vial should be dissolved in 1.5 mL of water for inj.
IV: 500 mg to be dissolved in 10-20 mL of water for inj, added to suitable IV fluids if given for i
Contra Indications
Hypersensitivity to cloxacillin and other penicillins.
Concomitant live bacterial vaccines
Precautions
Patient w/ allergies esp beta-lactam allergy, asthma, history of seizure disorder.
Renal impairment.
Pregnancy and lactation.
Prolonged use may result in superinfection
Elimination of drug in neonates is slow; use caution
Monitoring Parameters
Observe for signs and symptoms of anaphylaxis during 1st dose.
Monitor CBC w/ differential (prior to initiating therapy and wkly thereafter), periodic BUN, creatinine, hepatic function.
Monitor PT if patient is taking warfarin concurrently
Pregnancy-Lactation
Interactions
May diminish the effect of BCG and typhoid vaccine.
May increase risk of methotrexate toxicity.
May diminish the therapeutic effect of Na picosulfate.
May decrease serum concentrations of mycophenolate.
May prolong bleeding time w/ anticoagulants.
Increased serum concentrations w/ probenecid.
Tetracycline may antagonise the bactericidal effect of cloxacillin.
Contraindicated (0)
Serious (11)
BCG vaccine live
cholera vaccine
demeclocycline
doxycycline
microbiota oral
minocycline
omadacycline
pacritinib
sarecycline
tetracycline
typhoid vaccine live
Adverse Effects
Side effects of Cloxacillin :
1-10%
Abdominal pain
Diarrhea
Nausea
<1%
Anemia
Elevated LFTs
Fever
Hypersensitivity
Nephritis
Pseudomembranous colitis
Seizures with extremely high doses &/or renal failure
Rash (maculopapular to exfoliative)
Vomiting
Vaginitis
Potentially Fatal: Anaphylaxis.
Mechanism of Action
Cloxacillin inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
Note
A Clox 125mg/5ml Powder for Suspension manufactured by Acme Laboratories Ltd.. Its generic name is Cloxacillin. A Clox is availble in Bangladesh.
Farmaco BD drug index information on A Clox Powder for Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.